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Antiplasmodial Activity and Cytotoxicity of Isolated Compound from the Stem Bark of Anthocleistaliebrechtsiana

Original Article

JOURNAL 372

Records of Natural Products
VOLUME & ISSUE
Year: 2016 Issue: 3 May-June
PAGES
p.287 - 293
STATISTICS
Viewed 2046 times.
AUTHORS
    Theodora K. Kowa, Denis Zofou, Roukayatou Mbouangouere, Michel F. Tala, Hippolyte K. Wabo, Ning-Hua Tan, Vincent P.K. Titanji and Pierre Tane
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

One new cerebroside derivative, namely liebrechtsianoside A (1), along with five known compounds: tetracosanoic acid (2), swertiaperennin (3), decussatin (4), swertianin (5) and β-sitosterol glucoside (6) were isolated from the the stem bark of Anthocleista liebrechtsiana . Their structures were elucidated by interpretation of NMR and MS data, and by comparison of these data with those reported in literature. Compound 1 showed the highest antiplasmodial activity against Dd2 chloroquine-resistant strain of Plasmodium falciparum.

 KEYWORDS
  • Anthocleista liebrechtsiana
  • loganiaceae
  • cerebroside
  • structure elucidation
  • antiplasmodial activity

SUPPORTING INFORMATION

Supporting Information
Download File 36-RNP-1412-267-SI.pdf (714.13 KB)