JOURNAL 602
Records of Natural Products
VOLUME & ISSUE
Year: 2016 Issue: 6 November-December
Year: 2016 Issue: 6 November-December
PAGES
p.708 - 713
p.708 - 713
STATISTICS
Viewed 2459 times.
Viewed 2459 times.
AUTHORS
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Desheng Liu, Yuling Huang, Chunmin Li, Liying Ma, Xiaohong Pan, Daneel Ferreira and Weizhong Liu
GRAPHICAL ABSTRACT
ABSTRACT
A new sesquiterpenoid derivative, named aspergiketone (1), along with seven known compounds (2-8) were isolated from the coastal saline soil fungus Aspergillus fumigatus. Their structures were elucidated by spectroscopic analysis, and by comparison of experimental and reported data. The absolute configuration of compound 1 was defined by X-ray diffraction analysis. Compound 1 was cytotoxic towards HL-60 and A549 cell lines with IC 50 values of 12.4 and 22.1 μ M , respectively.
KEYWORDS- Secondary metabolites
- Aspergillus fumigatus
- cytotoxic activity
- coastal saline soil
