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A New Sesquiterpenoid Derivative from the Coastal Saline Soil Fungus Aspergillus fumigatus

Original Article

JOURNAL 602

Records of Natural Products
VOLUME & ISSUE
Year: 2016 Issue: 6 November-December
PAGES
p.708 - 713
STATISTICS
Viewed 2513 times.
AUTHORS
    Desheng Liu, Yuling Huang, Chunmin Li, Liying Ma, Xiaohong Pan, Daneel Ferreira and Weizhong Liu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new sesquiterpenoid derivative, named aspergiketone (1), along with seven known compounds (2-8) were isolated from the coastal saline soil fungus Aspergillus fumigatus. Their structures were elucidated by spectroscopic analysis, and by comparison of experimental and reported data. The absolute configuration of compound 1 was defined by X-ray diffraction analysis. Compound 1 was cytotoxic towards HL-60 and A549 cell lines with IC 50 values of 12.4 and 22.1 μ M , respectively.

 KEYWORDS
  • Secondary metabolites
  • Aspergillus fumigatus
  • cytotoxic activity
  • coastal saline soil

SUPPORTING INFORMATION

Supporting Information
Download File 83-RNP-1506-120-SI.pdf (412.34 KB)