Bioactive Dammarane Triterpenoids from the Bark of Drypetes acuminata from Paluma, North Queensland, Australia

Two known triterpenoids, friedelin and aglaitriol, and a new dammarane triterpenoid, aglaitriol 3-caffeate, have been isolated and identified in the chloroform bark extract of Drypetes acuminata P.I. Forst. (Putranjivaceae) from Paluma, north Queensland, Australia. The compounds were screened for antimicrobial and cytotoxic activity. Aglaitriol showed potent cytotoxic activity against three human tumor cell lines (MCF-7, MDA-MB-231, and 5637). Aglaitriol 3-caffeate showed moderate antibacterial activity against Staphylococcus aureus and Escherichia coli. A molecular docking analysis suggests topoisomerase II may be a likely protein target for aglaitriol.