Phytochemical Characterizationand in vivo Anti-inflammatory and Wound-healing Activities of Argania spinosa (L.) Skeels Seed Oil

The extracted oil of Argania spinosa (L.) was investigated in regard to its fatty acid composition and polyphenols by Gas Chromatography-Mass Spectrometry (GC–MS) and Ultra-high Performance Liquid Chromatography-Electro Spray Ionization-Quadruple Time Of Flight-Mass Spectrometry (UPLC-ESI-QTOF-MS), respectively. The reduction rate of topical inflammation of extracted oil was calculated using a mouse model. The skin toxicity of argan oil on intact and damaged skin was assessed using a rabbit model. The findings revealed a rich content of monounsaturated and polyunsaturated fatty acids and presence of phenolic acids. The oil exhibited a reduction of inflammation and facilitated a healing process without any irritation. The experimental study revealed that A. spinosa seed oil displays remarkable wound-healing and anti-inflammatory activities related to its chemical composition. Argan oil has positive potential for skin medicinal application.