New 5-oxomilbemycins from a Genetically Engineered Strain Streptomyces bingchenggensis BCJ60
Records of Natural Products
Year: 2017 Issue: 5 September-October
p.431 - 438
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Jiansong Li, Hui Zhang, Shaoyong Zhang, Haiyan wang, Ji Zhang, Anliang Chen, Jidong Wang and Wensheng Xiang
Two new 5-oxomilbemycins, 27-aldehyde -5-oxo milbemycin β 12 (1) and 2-hydroxymilbemycin K (2) , were isolated from a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined by comprehensive analyses of its 1H and 13C NMR, COSY, HMQC, and HMBC spectroscopic, HR - E S I - MS mass spectrometric and comparison with data from the literature . Preliminary studies showed that 27-aldehyde -5-oxo milbemycin β 12 (1) and 2-hydroxymilbemycin K (2) possessed strong acaricidal and nematocidal activities.KEYWORDS
- New 5-oxomilbemycins
- genetically engineered strain
- Streptomyces bingchenggensis BCJ60
- acaricidal and nematocidal activities.