Inhibition Effects of Some Lignans on Carbonic Anhydrase, Acetylcholinesterase and Butyrylcholinesterase Enzymes

Lignans are a large group of chemical compounds found in plants. They also have effects on enzymes, protein synthesis, proliferation, angiogenesis, growth factor and cell differentiation. In this study, α-(-)-conidendrin, enterodiole, enterolactone, nordihydroguaiaretic acid, secoisolariciresinol, and secoisolariciresinol diglucoside were used. Also, the inhibition effects of these lignans against the carbonic anhydrase CA I and II isoenzymes (CA I, and II) and acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated. The Ki values of the lignans were found in range of 1.7-3.30 nM for CA I, in range of 1.11-2.68 nM for CA II, in range of 0.72-1.62 nM for AChE, and in range of 0.08-0.20 nM for AChE, respectively.