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Antileishmanial Activity of a New ent-Kaurene Diterpene Glucoside Isolated from Leaves of Xylopia excellens R.E.Fr. (Annonaceae)

Short Report

JOURNAL 44

Records of Natural Products
VOLUME & ISSUE
Year: 2018 Issue: 2 March-April
PAGES
p.190 - 194
DOI ADDRESS
http://doi.org/10.25135/rnp.16.17.06.111
STATISTICS
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AUTHORS
    Danielle C. Alencar, Felipe M. A. da Silva, Richardson A. de Almeida, Emmanoel V. Costa, Lívia M. Dutra, Andersson Barison, Helito Volpato, Celso V. Nakamura, Hector H. F. Koolen, Afonso Duarte L. de Souza and Maria Lúcia B. Pinheiro
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

This work describes a new ent-kaurene diterpene glucoside, 7β-O-β-D-glucopyranoside-ent-kaur-16-ene, from the leaves of Xylopia excellens R.E.Fr. (Annonaceae). The compound showed high in vitro antileishmanial activity (IC 50 of 15.23 ± 0.64 µg/mL) towards promastigote forms of Leishmania amazonensis, and low cytotoxicity against J774A1 cells (SI of 1.96).

 KEYWORDS
  • Annonaceae
  • ent-kaurene diterpene
  • Leishmania amazonensis
  • Xylopia excellens.

SUPPORTING INFORMATION

Supporting Information
Download File 16-RNP-1706-111_SI.pdf (2.07 MB)