JOURNAL 65


Records of Natural Products
VOLUME & ISSUE
Year: 2018 Issue: 4 July-August
PAGES
p.391 - 396
STATISTICS
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AUTHORS
    Chalermlat Suktap, Hyeong Kyu Lee , Surattana Amnuaypol , Rutt Suttisri and Suchada Sukrong
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GRAPHICAL ABSTRACT


ABSTRACT


Five known flavonoid glycosides namely, juglanin (1), astragalin (2), nicotiflorin (3), isoquercetin (4) and apigenin-7-O- b -glucuronide (5), and a phenolic glucoside, arbutin (6), were isolated for the first time from the leaves of Afgekia mahidolae (Fabaceae). Their structures were elucidated using one- and two-dimensional NMR spectroscopic methods and comparison with the literature. The ability of 1-4 to promote the migration of CCD-1064sk fibroblasts into a scratch-wound area was evaluated. The results indicated that juglanin (1) and nicotiflorin (3) significantly increased the migration of these cells and, hence, supporting the wound healing effect of flavonol glycosides.

KEYWORDS
  • Afgekia mahidolae
  • fibroblasts
  • flavonoid glycosides
  • scratch-wound healing