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Isolation and Antimicrobial Activity of Rutin and Its Derivatives from Ruta chalepensis (Rutaceae) Growing in Iraq

Original Article

JOURNAL 859

Records of Natural Products
VOLUME & ISSUE
Year: 2019 Issue: 1 January-February
PAGES
p.64 - 70
DOI ADDRESS
http://doi.org/10.25135/rnp.74.18.03.250
STATISTICS
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AUTHORS
    Shaymaa Al-Majmaie, Lutfun Nahar, George P. Sharples, Khazal Wadi and Satyajit D. Sarker
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Rutin (1), rutin 3'-methyl ether (2), and a new flavonol glycoside, 6-hydroxy-rutin 3',7-dimethyl ether (3), were isolated from the methanol extract of the fruits of Ruta chalepensis , collected from Diyala, Iraq. Their structures were elucidated by spectroscopic analyses, including 1D-, 2D-NMR and HR ESI MS. Antimicrobial activity of compounds 1-3 was tested against four Gram +ve and Gram –ve bacterial strains, and the only fungal strain, Candida albicans, using the 96-well based resazurin microtitre assay.

 KEYWORDS
  • Ruta chalepensis
  • Rutaceae
  • resazurin assay
  • antimicrobial activity
  • rutin
  • 6-hydroxy-rutin 3‵
  • 7-dimethyl ether

SUPPORTING INFORMATION

Supporting Information
Download File 74-RNP-1803-250-SI.pdf (1.1 MB)