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Histone Deacetylase Inhibitor Induced Lipase Inhibitors from Endophytic Phomopsis sp. 0391

Original Article

JOURNAL 1243

Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 1 January-February
PAGES
p.42 - 47
DOI ADDRESS
http://doi.org/10.25135/rnp.134.19.01.1243
STATISTICS
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AUTHORS
  • Shan-ling Sheng
  • Yan-ping Li
  • Hai-ying Xiang
  • Yun Liu
  • Yudan Wang
  • Ling-peng Kong
  • Gang Du
  • Qiufen Hu
  • Yi-jian Chen
  • Weiguang Wang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Abstract: Seven compounds including a new one named as 13-angeloyloxy-diplosporin (1) were isolated from the endophytic Phomopsis sp. 0391 cultivated in the presence of a histone deacetylase inhibitor. All of these isolates were evaluated for lipase suppressive activities and we firstly found that compounds cytosporone B (5) and dothiorelone A (6) displayed significant lipase inhibited activities compared to the positive control (Orlistat, IC50 = 43 μg/mL) with the IC50 values at 115 and 275 μg/mL, respectively.

 KEYWORDS
  • Natural products
  • Endophytic fungi
  • Chemical epigenetics approach
  • Lipase inhibitor

SUPPORTING INFORMATION

Supporting Information
Download File A5-134-RNP-1904-1243-SI.pdf (842.79 KB)