JOURNAL 1406
Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 3 May-June
Year: 2020 Issue: 3 May-June
PAGES
p.171 - 176
p.171 - 176
STATISTICS
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Viewed 2445 times.
AUTHORS
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Kiem Van Phan
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Nguyen Thi Mai
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Hoang Thi Tuyet Lan
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Bui Thi Mai Anh
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Vu Van Doan
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Bui Huu Tai
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Nguyen Xuan Nhiem
GRAPHICAL ABSTRACT
ABSTRACT
A new sesquiterpene, schisandrathera E (1) and seven dibenzocyclooctadiene lignans as schisantherin D (2), schisantherin B (3), tigloylgomisin P (4), schisphenin E (5), angeloylgomisin H (6), (+)-deoxyschizandrin (7), and (+)-gomisin K3 (8) were isolated from the leaves of Schisandra sphenanthera Rehder & E.H.Wilson. Their structures were elucidated by spectroscopic and mass spectrometric analyses, including 1D-, 2D-NMR, HR-ESI-MS and ECD spectra. Compound 1 displayed moderate cytotoxicity against both PC3 and MCF4 cell lines in MTT assay with IC50 values of 22.60 and 7.80 µM, respectively.
KEYWORDS- Schisandra sphenanthera
- schisandrathera E
- sesquiterpene
- dibenzocyclooctadiene
