JOURNAL 1448
Records of Natural Products
Year: 2020 Issue: 3 May-June
p.213 - 218
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Valeria Romanucci
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Maria Giordano
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Sergio Davinelli
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Cinzia Di Marino
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Afef Ladhari
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Anna De Marco
GRAPHICAL ABSTRACT
ABSTRACT
Gymnema sylvestre is a commonly used herb in Ayurvedic medicine. The demand for its extracts in the commercial and pharmaceutical fields has been steadily increasing in recent years. Its extracts are used to treat various ailments as well as for their antimicrobial properties. This study has evaluated the antimicrobial effects of different G. sylvestre extracts and of eight triterpenes isolated from the most active extract on six bacterial poultry pathogens i.e. Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Enterobacter aerogenes. In particular, it has been evaluated the minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of all extracts and isolated triterpenes. Finally, the cytotoxicity activity of triterpenes was evaluated by MTT assay and their antioxidant activity in basal and oxidant conditions by DCFH-DA assay.
KEYWORDS- Gymnema sylvestre
- antimicrobial effects
- triterpenes
- gymnemic acids
- herbal drug
- DCFH-DA assay
