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Steroidal Components from the Roots and Rhizomes of Smilacina henryi and Their Cytotoxic Activities

Short Report

JOURNAL 1390

Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 3 May-June
PAGES
p.225 - 230
DOI ADDRESS
http://doi.org/10.25135/rnp.156.1908.1390
STATISTICS
Viewed 2223 times.
AUTHORS
  • Zhenlin Chen
  • Xuanji Xue
  • Shuo Zhang
  • Rongxin Zhang
  • Xiulei Zhang
  • Zengjun Guo
  • Xin Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Nine steroidal components, including a new pregnane glycoside (1), were obtained from the roots and rhizomes of Smilacina henryi. Their structures were determined via extensive spectroscopic data including, IR, HRESIMS and 1D, 2D NMR data analysis. Furthermore, their cytotoxic activities against human HepG2 and SW620 tumor cells were evaluated by the MTT method and compounds 2, 3, 5, 8 and 9 showed moderate activity with IC50 values raging from 18.4 to 86.3 μM.

 KEYWORDS
  • Smilacina henryi
  • steroidal components
  • structure identifition
  • cytotoxicity

SUPPORTING INFORMATION

Supporting Information
Download File A10-156-RNP-1908-1390-SI.pdf (1.29 MB)