JOURNAL 1342
Records of Natural Products
Year: 2020 Issue: 4 July-August
p.276 - 285
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Melissa Salinas
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Nicole Bec
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James Calva
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Jorge Ramirez
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José Miguel Andrade
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Christian Larroque
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Giovanni Vidari
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Chabaco Armijos
GRAPHICAL ABSTRACT
ABSTRACT
Salvia pichinchensis Benth was collected in the South of Ecuador and the essential oil (EO) was distilled from aerial parts and analyzed by GC-MS and GC-FID. The physical properties, chemical composition, and cholinesterase inhibitory activity were determined. Six major components, all sesquiterpenes, were identified: cis-cadina-1(6),4-diene (17.11%) (1),γ-curcumene (13.75%) (2), (E)-caryophyllene (12.58%) (3), (E,E)-α-farnesene (10.00%) (4), α-gurjunene (9.46%) (5) and allo-aromadendrene (6.96%) (6). The EO showed an interesting selective inhibitory activity against the enzyme butyrylcholinesterase (50.70 μg/mL) and only low inhibitory activity against acetylcholinesterase (117.60 μg/mL). The chemical composition and butyrylcholinesterase activity of the EO of S. pichinchensis Benth was reported for first time.
KEYWORDS- Salvia pichinchensis
- essential oil
- GC-MS analysis
- in vitro ChE inhibitory activity
- cis-cadina-1(6),4-diene
