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A New Lignan Glycoside from the Roots of Silene tatarinowii Regel

Short Report

JOURNAL 1529

Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 6 November-December
PAGES
p.405 - 409
DOI ADDRESS
http://doi.org/10.25135/rnp.187.20.01.1529
STATISTICS
Viewed 2353 times.
AUTHORS
  • Xiaofei Liang
  • Yuze Li
  • Yuwen Cui
  • Zhuofei Liang
  • Wenli Huang
  • Yi Jiang
  • Huawei Zhang
  • Xiaomei Song
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new lignan glycoside, siletatoside A (1), and three known lignans, (+)-isolariciresinol (2), balanophonin (3), and (+)-lariciresinol (4), were isolated from the roots of Silene tatarinowii Regel. Compounds 2–4 were isolated from the Silene genus for the first time. Their structures were determined based on physicochemical properties and spectroscopic methods. The structure of siletatoside A was elucidated for the first time. The cytotoxicity of 1–4 was evaluated in vitro in human HCT116, HT29, A549, and H1299 tumor cell lines. These compounds displayed weak cytotoxicity in the human cancer cell lines. 

 KEYWORDS
  • Silene tatarinowii
  • lignan
  • siletatoside A
  • cytotoxicity

SUPPORTING INFORMATION

Supporting Information
Download File A3-187-RNP-2001-1529-SI.pdf (2 MB)