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Cytotoxic Activity and Phytochemical Constituents of Macrosolen bidoupensis Tangane & V.S. Dang

Short Report

JOURNAL 1545

Records of Natural Products
VOLUME & ISSUE
Year: 2021 Issue: 1 January-February
PAGES
p.71 - 75
DOI ADDRESS
http://doi.org/10.25135/rnp.197.20.02.1545
STATISTICS
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AUTHORS
  • Kieu Hung Le
  • Tran Canh Nguyen
  • The Anh Nguyen
  • Nu Dan Phuong Nguyen
  • Thi Hong Tuoi Do
  • Le Thanh Tuyen Nguyen
  • Van Son Dang
  • Trong Duc Tran
  • Nhat Minh Phan
  • Trong Dat Bui
  • Dinh Tri Mai
  • Tan Phat Nguyen
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Phytochemical investigations of the whole plants of Macrosolen bidoupensis Tangane & V.S. Dang, a new species discovered in Viet Nam were conducted and led to the purification of ten compounds, comprising three lupane-type (1-3), three friedelane-type (4-6), and one glutinane-type (7) triterpenoids and three cholestane-type steroids (8-10) using various chromatographic methods. Their structures were characterized by HR-ESI-MS, NMR experiments and comparison with previous literature.  Compounds 1, 3 and 5 expressed moderate cytotoxicity against two tested cell lines - MDA-MB-231 and RD (IC50 ranged from 34.19 to 74.25 μM), whereas compounds 4 and 6 exhibited selective cytotoxic activity (IC50 ranged from 29.07 to 45.20 μM).

 KEYWORDS
  • Macrosolen bidoupensis
  • Loranthaceae
  • cytotoxic activity
  • triterpenoid
  • steroid

SUPPORTING INFORMATION

Supporting Information
Download File A9-197-RNP-2002-1545-SI.pdf (2.69 MB)