JOURNAL 1728
Records of Natural Products
Year: 2021 Issue: 2 March-April
p.130 - 135
Viewed 1769 times.
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Ronglu Yu
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Mingzhu Li
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Yi Wang
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Xuelian Bai
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Jianwei Chen
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Xingnuo Li
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Hong Wang
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Huawei Zhang
GRAPHICAL ABSTRACT
ABSTRACT
Chemical investigation of a co-culture of two endophytic fungi Aspergillus fumigatus D and Fusarium oxysporum R1 from two traditional medicinal plants, Edgeworthia chrysantha Lindl. and Rumex madaio Makino, led to isolation of a new amide 1 and six known compounds, including neovasinin (2), neovasifuranone B (3), N-(2-phenylethyl)acetamide (4), α-linolenic acid (5), α-elaeostearic acid (6), palmitoleic acid (7). On the basis of extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS and optical rotation measurement as well as comparison of literature data, chemical structure of 1 was unambiguous elucidated as (S, E)-methyl-2-(2,4-dimethylhex-2-enamido)acetate. Bioassay results indicated that none of these compounds exhibited strong inhibitory effect on three human pathogens Escherichia coli, Staphyloccocus aureus and Candida albicans with MIC values of ≥25 μM.
KEYWORDS- Endophytic fungus
- Aspergillus fumigatus D
- Fusarium oxysporum R1
- co-culture
- amide
- antimicrobial effect
