JOURNAL 1935
Records of Natural Products
VOLUME & ISSUE
Year: 2021 Issue: 5 September-October
Year: 2021 Issue: 5 September-October
PAGES
p.356 - 362
p.356 - 362
STATISTICS
Viewed 1742 times.
Viewed 1742 times.
GRAPHICAL ABSTRACT
ABSTRACT
A new coumarin, angedahurin A (1), and seven known analogues (2−8), were isolated from the roots of Angelica dahurica. Their structures were identified by extensive NMR, IR, and HR-ESIMS spectroscopic analyses. The cytotoxicities of coumarins 1−8 against MG-63 human osteosarcoma cell lines were screened. Compound 1 showed significant cytotoxic effects against MG-63 with an IC50 value of 7.2 uM，for comparison, the positive control, 5-FU, had an IC50 value of 32.4 uM. Morphological features of apoptosis activities were evaluated in 1-induced MG-63 cells and the results confirmed MG-63 cell apoptosis in a dose-dependent manner.
KEYWORDS- Angelica dahurica
- coumarin
- apoptosis
- cytotoxicity
