JOURNAL 1889
Records of Natural Products
VOLUME & ISSUE
Year: 2021 Issue: 5 September-October
Year: 2021 Issue: 5 September-October
PAGES
p.414 - 419
p.414 - 419
STATISTICS
Viewed 1947 times.
Viewed 1947 times.
AUTHORS
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Mohamad Nurul Azmi
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Nur Amirah Saad
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Mohamad Hafizi Abu Bakar
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Mohammad Tasyriq Che Omar
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Ahmad Nazif Aziz
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Habibah A. Wahab
-
Sadia Siddiq
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M. Iqbal Choudhary
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Marc Litaudon
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Khalijah Awang
GRAPHICAL ABSTRACT
ABSTRACT
A phytochemical investigation of the methanolic extract of Endiandra kingiana (bark) led to the isolation of four major compounds which are kingianic acid A (1), tsangibeilin B (2), kingianin A (3) and kingianin F (4). The structures were determined by 1D- and 2D-NMR analysis in combination with HRMS experiments. The compounds were screened for their in vitro α-glucosidase inhibition activity. Among them, compounds 3-4 showed potent α-glucosidase inhibition activity with IC50 value at 11.9 ± 2.0 µM and 19.7 ± 1.5 µM, respectively. The molecular docking study found that both compounds were bound into the active site of the N-terminal of MGAM, and thus agreed with the in vitro α-glucosidase enzyme inhibition activity results.
KEYWORDS- Endiandra kingiana
- cyclic polyketides
- Endiandric acids
- kingianins
- α-glucosidase inhibition
- molecular docking
