Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034

Short Report

JOURNAL 1766

Records of Natural Products

VOLUME & ISSUE

Year: 2021 Issue: 6 November-December (Special Issue Dedicated to the Memory of Professor Ayhan Ulubelen)

PAGES

p.602 - 607

DOI ADDRESS

http://doi.org/10.25135/rnp.203.20.08.1766

STATISTICS

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AUTHORS

Semiha Çetinel Aksoy
Melis Küçüksolak
Ataç Uzel
Erdal Bedir

GRAPHICAL ABSTRACT

ABSTRACT

7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D- (1H and 13C NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.

KEYWORDS

Marine actinobacterium
Streptomyces cacaoi
Benzodiazepine
Antimicrobial activity
Antibiotics

SUPPORTING INFORMATION

Supporting Information

Download File A14-203-RNP-2008-1766-SI.pdf (786.86 KB)