JOURNAL 2010


Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 1 January-February
PAGES
p.104 - 109
STATISTICS
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AUTHORS
  • Grant Currens
  • Umesh Sankpal
  • Riyaz Basha
  • Eric Cheng
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


In the process of piloting a new approach to natural product discovery from microorganisms isolated from systematically determined geographic sites in the State of Texas, USA, two previously identified and structurally similar bioactive pentacyclic aspochalasins, aspergillin PZ (1) and trichoderone B (2), were re-discovered from a single isolate of Aspergillus flavipes sp.. While the antimicrobial activity and cytotoxic activity of 1 had been documented in several publications, nothing was known about the bioactivities of 2. After a large laboratory-scale fermentation and activity-guided purification, both 1 and 2 were enrolled in the NCI-60 Human Tumor Cell Lines Screen program. A preliminary single-dose assay of two natural products shows a similar cytotoxic profile and a low potency against human tumor cell lines with few exceptions at the 10 µM dosage level.

KEYWORDS
  • Aspergillin PZ
  • Trichoderone B
  • Aspergillus flavipes
  • Natural product
  • Cytotoxic activity

SUPPORTING INFORMATION


Supporting Information
Download File A11-254-RNP-2103-2010-SI.pdf (956.68 KB)