JOURNAL 2138
Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 3 May-June
Year: 2022 Issue: 3 May-June
PAGES
p.264 - 267
p.264 - 267
STATISTICS
Viewed 2005 times.
Viewed 2005 times.
GRAPHICAL ABSTRACT
ABSTRACT
Phytochemical investigation of the fruits of Rosa roxburghii resulted in the isolation of four organic acid derivatives and three phenylpropanoids, including a new organic acid derivative, Roxbuacidester A (1) and six known compounds (2-7). The structures of all isolates were established by 1D and 2D NMR spectra referring to the literatures, together with HR-MS spectrometric analysis. In addition, compounds 1 and 2 were evaluated for their inhibitory activities on nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in a RAW 264.7 cell line. Compounds 1 and 2 showed moderate inhibition of NO production with IC50 values of 46.8 ± 2.3 and 62.5 ± 3.7 μM, respectively.
KEYWORDS- Rosaceae
- Rosa roxburghii
- organic acid derivative
