JOURNAL 2145
Records of Natural Products
Year: 2022 Issue: 4 July-August
p.393 - 397
Viewed 2039 times.
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Guoqing Wu
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Zilong Zhang
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Hao Fan
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Dongdong Zhang
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Wenli Huang
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Huawei Zhang
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Yuze Li
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Xiaomei Song
GRAPHICAL ABSTRACT
ABSTRACT
A new iridoid glycoside, (5S,7S,8S,9R)-7- hydroxy-∆4,11-dihyronepeta-1,3-diol-8-O-β-D-glucopyranosyl (1), along with 5 known compounds, dioscoridin A (2), jatamanin J (3), longiflorone (4), apigenin-8-O-β-D-glucopyranoside (5), isosakuranetin-5-O-rutinoside (6), were isolated from the Valeriana officinalis L. Their structures were determined by extensive analysis using various spectroscopic techniques. Moreover, the cytotoxic activity assay toward three human tumor cell (A549, HCT116 and SW620) lines were evaluated by the MTT method in vitro for compounds 1-2, using cisplatin as positive control. Experimental results showed that these compounds displayed weak cytotoxicity in the human cancer cell lines. Notably, compounds 2, 3 and 6 were firstly isolated from this plant, compound 4 was isolated from the genus Valeriana for the first time, compound 5 was isolated for the first time from Valerianaceae family.
KEYWORDS- Iridoids
- Valeriana officinalis L.
- Valerianaceae
- cytotoxicity
