JOURNAL 2203
Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 4 July-August
Year: 2022 Issue: 4 July-August
PAGES
p.404 - 408
p.404 - 408
STATISTICS
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Viewed 2079 times.
GRAPHICAL ABSTRACT
ABSTRACT
A new isoflavan glucoside, namely astramemside A (1), together with six known compounds (2-7) were obtained from the roots of a traditional Chinese medicine, Astragalus membranaceus var. mongholicus. Their structures were elucidated by spectroscopic analyses (HRESIMS, UV, IR, 1D and 2D NMR), and the absolute configuration of 1 was determined by combination of chemical transformation and single-crystal X-ray diffraction. Compound 1 showed moderate inhibition on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with an IC50 value of 38.98 ± 5.28 uM.
KEYWORDS- Astragalus membranaceus var. mongholicus
- Leguminosae
- isoflavan glucoside
