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Fissistigmol A: A New Polyacetylene alcohol from Fissistigma Minuticalyx

Short Report

JOURNAL 2156

Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 4 July-August
PAGES
p.382 - 386
DOI ADDRESS
http://doi.org/10.25135/rnp.280.2108.2156
STATISTICS
Viewed 1881 times.
AUTHORS
  • Ping Yang
  • Ji Song
  • Mi Zhang
  • Shiyun Jiao
  • Weifeng Dai
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Abstract:  A new polyacetylene alcohol, Fissistigmol A (1), along with four known polyacetylene alcohol compounds (2-5) were isolated from the aerial part of Fissistigma minuticalyx (McGr. et W. W. Sm.). Their structures were elucidated based on the spectroscopic evidence, mainly including NMR and induced ECD, and HRESIMS data. In addition, bioactivity assay showed that 1-5 showed notable nitric oxide (NO) inhibitory effects (IC50 < 10 μM) on the model of the lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.

 KEYWORDS
  • Polyacetylene alcohol
  • Annonaceae
  • Fissistigma minuticalyx
  • nitric oxide (NO) inhibitory activity

SUPPORTING INFORMATION

Supporting Information
Download File A12-280-RNP-2108-2156-SI.pdf (1.05 MB)