JOURNAL 2121
Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 4 July-August
Year: 2022 Issue: 4 July-August
PAGES
p.316 - 323
p.316 - 323
STATISTICS
Viewed 1784 times.
Viewed 1784 times.
AUTHORS
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Chi-I Chang
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Cheng-Chi Chen
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Sheng-Yang Wang
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Jih-Jung Chen
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Chiy-Rong Chen
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Che-Yi Chao
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Yueh-Hsiung Kuo
GRAPHICAL ABSTRACT
ABSTRACT
Two new seco-abietanoids, 12-hydroxy-6-nor-5,6-secoabieta-8,11,13-trien-7-oic acid (1) and 7-hydroxy-7,8-secoabieta-8,12-diene-6,11,14-trione (3), together with one known seco-abietanoid, 12-hydroxy-6-nor-5-oxo-5,6-secoabieta-8,11,13-trien-7-al (2), were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated by mean of spectroscopic analysis, as well as on comparison of NMR data with those of known analogues. At a concentration of 50 μM, compounds 1–3 showed inhibitory activity toward xanthine oxidase by 38.2%, 55.9%, and 23.0%, respectively.
KEYWORDS- Cupressaceae
- Cryptomeria japonica
- bark
- diterpenoid
