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Cytotoxic Drimane-type Sesquiterpenoids from the Fungus Aspergillus flavipes 297

Short Report

JOURNAL 2194

Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 5 September-October
PAGES
p.488 - 492
DOI ADDRESS
http://doi.org/10.25135/rnp.294.2109.2194
STATISTICS
Viewed 1804 times.
AUTHORS
  • Liancheng Xu
  • Shiping Wang
  • Xiang Ji
  • Changming Huang
  • Pengfei Hu
  • Weihuan Luo
  • Shan Liu
  • Yu Chen
  • Guodong Liu
  • Guanyi Cao
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Chemical investigation of the marine-derived fungus Aspergillus flavipes 297 led to the isolation and identification of three drimane-type sesquiterpenoids, asperflavinoid A (1) and (6-strobilactone-B) esters of (E,E)-6,7-dihydroxy-2,4-octadienoic acids (2 and 3). Asperflavinoid A (1) was characterized as unseparated diastereomers and its chemical structure was determined by spectroscopic analysis of NMR and MS data. In the cytotoxic assay, compound 1 showed promising inhibitory effects on HepG2 and MKN-45 cell lines.

 KEYWORDS
  • Aspergillus flavipes
  • natural products
  • drimane sesquiterpenoids
  • cytotoxicity

SUPPORTING INFORMATION

Supporting Information
Download File A11-294-RNP-2109-2194-SI.pdf (988.19 KB)