JOURNAL 2194
Records of Natural Products
VOLUME & ISSUE
Year: 2022 Issue: 5 September-October
Year: 2022 Issue: 5 September-October
PAGES
p.488 - 492
p.488 - 492
STATISTICS
Viewed 1899 times.
Viewed 1899 times.
AUTHORS
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Liancheng Xu
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Shiping Wang
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Xiang Ji
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Changming Huang
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Pengfei Hu
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Weihuan Luo
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Shan Liu
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Yu Chen
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Guodong Liu
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Guanyi Cao
GRAPHICAL ABSTRACT
![](/fotograf/1634864849_graphical_abstract.jpg)
ABSTRACT
Chemical investigation of the marine-derived fungus Aspergillus flavipes 297 led to the isolation and identification of three drimane-type sesquiterpenoids, asperflavinoid A (1) and (6-strobilactone-B) esters of (E,E)-6,7-dihydroxy-2,4-octadienoic acids (2 and 3). Asperflavinoid A (1) was characterized as unseparated diastereomers and its chemical structure was determined by spectroscopic analysis of NMR and MS data. In the cytotoxic assay, compound 1 showed promising inhibitory effects on HepG2 and MKN-45 cell lines.
KEYWORDS- Aspergillus flavipes
- natural products
- drimane sesquiterpenoids
- cytotoxicity