JOURNAL 2437


Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 1 January-February
PAGES
p.165 - 169
STATISTICS
Viewed 2481 times.
AUTHORS
  • Bingyao Huang
  • Humu Lu
  • Yanting Zhang
  • Xia Gan
  • Xueni Wang
  • Yong-Hong Liu
  • Xiaowei Luo
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The Beibu Gulf represents an underexplored reservoir of marine micro-/organisms and secondary metabolites. Three uncommon 4-hydroxy-2-pyridone alkaloids and one phenazine alkaloid were obtained from the Beibu Gulf coral-associated fungus Acremonium sclerotigenum GXIMD 02501 via OSMAC approach. They were identified as campyridones D (1) and A (2), ilicicolin H (3), and phenazine-1-carboxylic acid (4), respectively, by spectroscopic analysis and comparison with literature values. All of them were evaluated for cytotoxic, anti-Vibrio, and NF-κB luciferase inhibitory activities. Compounds 2 and 3 showed cytotoxicity against two prostate cancer cell lines, with IC50 values of 17.6 ± 1.3 and 5.5 ± 1.2 μM for PC-3, while 25.4 ± 1.7 and 11.9 ± 1.3 μM for 22Rv1, respectively. Besides, compound 4 showed promising anti-Vibrio activity with MIC values of 0.047–0.067 mg/mL and also displayed inhibition of LPS-induced NF-κB activation at 10 μM.

KEYWORDS
  • Acremonium sclerotigenum
  • coral-associated fungi
  • alkaloids
  • bioactivity
  • cytotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File A10-329-RNP-2204-2437-SI.pdf (7.82 MB)