Plagranline A, a Novel β-carboline and the First Alkaloid Isolated from Platycodon grandiflorus

Short Report

JOURNAL 2510

Records of Natural Products

VOLUME & ISSUE

Year: 2023 Issue: 2-March-April

PAGES

p.377 - 381

DOI ADDRESS

http://doi.org/10.25135/rnp.354.2207.2510

STATISTICS

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AUTHORS

Ju-Tao Wang
Lan Ding
Ren-nai Yang
Liang-ping Zha
Yang Yu
Shuang-ying Gui

GRAPHICAL ABSTRACT

ABSTRACT

A novel β-carboline, namely Plagranline A (1), and a known alkaloid (2) were isolated from the roots of Platycodon grandiflorus. Their structure was elucidated using a combination of spectroscopic analyses and computational chemistry, including electronic circular dichroism (ECD) and optical rotatory dispersion (ORD). Alkaloids 1 and 2 exhibited moderate inhibitory effects against NO production. Interestingly, 1 and 2 are the first alkaloid constituents reported from the plant P. grandifloras.

KEYWORDS

Platycodon grandiflorus
β-carboline
computational chemistry
alkaloid
anti-inflammatory activity

SUPPORTING INFORMATION

Supporting Information

Download File 354-RNP-2207-2510-SI.pdf (2.01 MB)

Supporting Information

Download File A19-354-RNP-2207-2510-SI.pdf (2.01 MB)