JOURNAL 2594
Records of Natural Products
Year: 2023 Issue: 3 May-June
p.549 - 554
Viewed 1953 times.
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Qiwan Zheng
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Canyue Quyang
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Yang Liu
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Jiahui Ren
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Xianwen Wei
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Ronghua Liu
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Lanying Chen
GRAPHICAL ABSTRACT
ABSTRACT
A new benzofuran, Cochinfuran A (1), and four known benzofurans (2-5) were isolated from the heartwood of Dalbergia cochinchinensis Pierre ex Laness. The chemical structure of the new benzofuran was determined based on broad NMR and mass spectrometry evaluation. Bioactivity assays showed that the compounds 1-3 and 5 were found as anti-inflammatory agents with IC50 values 49.01 ± 1.54, 1368.93 ± 0.98, 67.48 ± 0.92 and 77.91 ± 1.53 μM, respectively. They could reduce the production of NO (P<0.001) with 3.52~7.04, 1.96~7.84, 1.85~7.40 and 0.98~3.93 μM and restrained LDH (P<0.01) with 3.52~7.04, 3.93~7.84, 3.70~7.40 and 0.98~3.93 μM in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, respectively, the compound 4 (IC50 218.20 ± 3.39 μM) showed no anti-inflammatory activity.
KEYWORDS- Dalbergia cochinchinensis Pierre
- benzofurans
- anti-inflammatory activity
