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A New Isobenzofuranone Derivative from Arctic Fungus Gyoerffyella sp. CPCC 401434

Short Report

JOURNAL 2629

Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 4 July-August
PAGES
p.731 - 736
DOI ADDRESS
http://doi.org/10.25135/rnp.392.2211.2629
STATISTICS
Viewed 1716 times.
AUTHORS
  • Bingyuan Zhang
  • Yan Tang
  • Zhe Guo
  • Jun Hu
  • Qingrong Du
  • Tao Zhang
  • Shengjun Dai
  • Baiping Ma
  • Liyan Yu
  • Dewu Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new isobenzofuranone derivative, (R)-3-acetyl-[5,7]-dimethoxy-3H-isobenzofuran-l-one (1), together with six known compounds, (R)-3-acetyl-7-hydroxy-5-methoxy-3H-isobenzofuran-l-one (2), banksialactone D (3), (3R,4S)-3,8-dihydroxy-3-hydroxymethyl-6-methoxy-4,5-dimethyl-isochroman-1-one (4), 1-O-[α-L-rhamnopyranosyl]-2,5-dimethyl-3-phenol (5), p-hydroxybenzaldehyde (6), 2-(4-hydroxyphenyl) ethanol (7), were isolated from Arctic fungus Gyoerffyella sp. CPCC 401434. Their structures and absolute configurations were elucidated by the analysis of spectroscopic data, electronic circular dichroism, and comparison with reported literature data. Herein, all compounds were reported for the first time from the genus Gyoerffyella and their cytotoxic and antibacterial activities.

 KEYWORDS
  • Arctic fungus
  • Gyoerffyella
  • isobenzofuranone
  • cytotoxicity

SUPPORTING INFORMATION

Supporting Information
Download File A16-392-RNP-2211-2629-SI.pdf (1.68 MB)