JOURNAL 2811
Records of Natural Products
Year: 2023 Issue: 5 September-October
p.896 - 903
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GRAPHICAL ABSTRACT
ABSTRACT
A new lignan, named 4'-methoxy-neotaiwanensol (1), together with five known compounds (2-6) were isolated from the leaves of the plant Piper sarmentosum. The known compounds consist of a phenylpropanoid (2), a flavonoid (3), two acyclic monoterpenoids (4 and 5), and a phenylacetic acid derivative (6). The structures of the know compounds were established via detailed analyses of the spectral data including NMR and HRESIMS data. The NMR data of 4 and 5 are new natural products and their NMR data in methanol-d4 were reported for the first time. The other known compounds were elucidated to be hydroxychavicol (2), salvitin (3), 4-hydroxy-benzeneacetic acid (6). In vitro, compounds 1 and 3 showed obvious antioxidant effects comparable to the positive control vitamin C, as well as better inhibitory effects on a-glucosidase than the reference acarbose.
KEYWORDS- Lignan
- Piper sarmentosum
- 4-Methoxy-neotaiwanensol
- monoterpenoid
