JOURNAL 2756
Records of Natural Products
Year: 2023 Issue: 5 September-October
p.845 - 859
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GRAPHICAL ABSTRACT
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ABSTRACT
To search for novel and bioactive agents from the genus Aglaia, phytochemical investigation on the leaves and twigs of A. perviridis was performed, leading to the isolation of twenty-six compounds. Their structure was determined mainly by the NMR, ESI-MS spectra data, and by comparison with previously described compounds. Compounds 6–8, 11–13, 16, 18–20, and 22–26 were firstly reported from Aglaia perviridis. Besides, the NO inhibitory, Farnesoid X receptor, and cytotoxic activities of selected compounds were firstly evaluated. 1αH,5αH-guaia-6-ene-4β,10β-diol (7), 2'-hydroxy-4,4',6'-trimethoxychalcone (22), and 3-hydroxy-5,7,4'-trimethoxyflavone (23) showed moderate nitric oxide inhibitory activity with IC50 values of 27.44±1.70, 22.29±1.53, and 19.29±3.96 µM, respectively; piscidinol A (11) and hispidol B (12) firstly showed moderate agonistic activities on Farnesoid X receptor with the EC50 values of 6.19±1.08 and 8.61±0.32 µM, respectively; Among these compounds, lochmolin F (6) exhibited the strongest cytotoxic effect on SiHa cells with the IC50 value of 19.58±0.21 μM. Further flow cytometry and western blot analysis demonstrated that lochmolin F (6) could induce cell apoptosis and S cell cycle arrest in the SiHa cells. These results first emphasized the potential of lochmolin F (6) as lead compound for developing anti-cancer drugs.
KEYWORDS- Aglaia perviridis
- phytochemical composition
- anti-inflammatory
- FXR
- cytotoxic activities