Nocardiopyrone C, a New Antimicrobial Pyran-2-one Derivative from a Marine-derived Actinomycete Strain Nocardiopsis aegyptia ZSN1

Short Report

JOURNAL 2763

Records of Natural Products

VOLUME & ISSUE

Year: 2023 Issue: 5 September-October

PAGES

p.952 - 957

DOI ADDRESS

http://doi.org/10.25135/rnp.405.2304.2763

STATISTICS

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AUTHORS

Yuhong Tian
Ziwen Chen
Mingzhu Ma
Jiang Yongjun

GRAPHICAL ABSTRACT

ABSTRACT

A new pyran-2-one derivative, Nocardiopyrone C (1), and three known compounds, Nocardiopyrone B (2), 1-hydroxy-4-methoxy-2-naphthoic acid (3), and 2-(aminocarbonyl)-phenylcarbamate (4) were identified from the marine-derived Nocardiopsis aegyptia ZSN1. The chemical structure of the novel compound (1) was ascertained as (7R)-5-(methoxymethyl)-3-methyl-6-(pentan-2-yl)-2H-pyran-2-one using HRESIMS data, spectroscopic data, and ECD calculations. All four isolated compounds displayed antimicrobial activity, with the new compound 1 having the same MIC value of 50.0 µM against E. coli, S. aureus, and C. albicans.

KEYWORDS

Nocardiopsis aegyptia
nocardiopyrone C
antimicrobial

SUPPORTING INFORMATION

Supporting Information

Download File A12-405-RNP-2304-2763-SI.pdf (1.16 MB)