JOURNAL 2776
Records of Natural Products
Year: 2023 Issue: 6 November-December
p.1024 - 1030
Viewed 1448 times.
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Do Thi Quynh
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Trinh Thi Thanh Van
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Nguyen Thuy Linh
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Le Thi Hong Minh
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Vu Thi Quyen
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Brian T. Murphy
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Doan Thi Mai Huong
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Pham Van Cuong
GRAPHICAL ABSTRACT
ABSTRACT
OA new alkaloid, isocyanogramide (1) together with six known compounds, including cyanogramide (2), marinacarboline F (3), marinacarboline H (4), caerulomycinamide (5), cerulomyconitrile (6), and 5ʹ-deoxyuridine (7) were isolated from the agar culture of the marine-derived actinomycete Actinoalloteichus cyanogriseus G631. Compounds 1-7 were evaluated for antimicrobial activity against Gram (+) bacteria, Enterococcus faecalis, Staphylococcus aureus, and Bacillus cereus, Gram-(–) bacteria, Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, and the yeast, Candida albicans. All compounds significantly exhibited antibacterial effects on three tested Gram-(+) bacteria and the yeast C. albicans with the MIC values ranging from 64 to 256 µg/mL. Compounds 4, 5, and 7 significantly inhibited B. cereus bacteria with MIC values of 16, 128, and 128 µg/mL, respectively.
KEYWORDS- Actinoalloteichus cyanogriseus
- marine actinomycetes
- isocyanogramide
- alkaloid
- antibacterial activity
- antifungal activity
