JOURNAL 2807


Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 6 November-December
PAGES
p.1064 - 1068
STATISTICS
Viewed 1681 times.
AUTHORS
  • Hao Geng
  • Wen-Jie Gu
  • Jia-Hui Luo
  • Yong-Xun Yang
  • Yang Yu
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Herein, the chemical analysis of petroleum ether extract of Eupatorium adenophorum was conducted which led to the identification of a previously unreported sesquiterpenoid, named eupatorione A (1). The structure of eupatorione A (1) was elucidated through comprehensive spectroscopic analysis, including 1D, 2D-NMR techniques, as well as HRMS. Additionally, X-ray diffraction was employed to further confirm the structure.  The anti-inflammatory activity of compound 1 was assessed by measuring its inhibitory effects on the production of nitric oxide (NO), induced by lipopolysaccharide (LPS) in RAW264.7 LPS-activated macrophages.

KEYWORDS
  • Compositae
  • Eupatorium adenophorum
  • sesquiterpenoid
  • chemical structure

SUPPORTING INFORMATION


Supporting Information
Download File A10-411-RNP-2306-2807-SI.pdf (1.59 MB)