Eupatorione A, an Unusual Sesquiterpenoid from the Aerial Parts of Eupatorium adenophorum

Short Report

JOURNAL 2807

Records of Natural Products

VOLUME & ISSUE

Year: 2023 Issue: 6 November-December

PAGES

p.1064 - 1068

DOI ADDRESS

http://doi.org/10.25135/rnp.23062807

STATISTICS

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AUTHORS

Hao Geng
Wen-Jie Gu
Jia-Hui Luo
Yong-Xun Yang
Yang Yu

GRAPHICAL ABSTRACT

ABSTRACT

Herein, the chemical analysis of petroleum ether extract of Eupatorium adenophorum was conducted which led to the identification of a previously unreported sesquiterpenoid, named eupatorione A (1). The structure of eupatorione A (1) was elucidated through comprehensive spectroscopic analysis, including 1D, 2D-NMR techniques, as well as HRMS. Additionally, X-ray diffraction was employed to further confirm the structure. The anti-inflammatory activity of compound 1 was assessed by measuring its inhibitory effects on the production of nitric oxide (NO), induced by lipopolysaccharide (LPS) in RAW264.7 LPS-activated macrophages.

KEYWORDS

Compositae
Eupatorium adenophorum
sesquiterpenoid
chemical structure

SUPPORTING INFORMATION

Supporting Information

Download File A10-411-RNP-2306-2807-SI.pdf (1.59 MB)