A New Aporphine Alkaloid from Litsea glutinosa to Attenuate Palmitate Induced Viability in MIN6 Cells

Original Article

JOURNAL 2875

Records of Natural Products

VOLUME & ISSUE

Year: 2024 Issue: 1 January-February

PAGES

p.155 - 160

DOI ADDRESS

http://doi.org/10.25135/rnp.427.2308.2875

STATISTICS

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AUTHORS

Yuanyuan Zhou
Zibao Huang
Chenpeng Liu
Guoyu Li
Xiaopo Zhang

GRAPHICAL ABSTRACT

ABSTRACT

A new alkaloid called Litsine E (1) and three known aporphine alkaloids (2-4) were isolated from Litsea glutinosa. The structure of the new compound was established using spectroscopic techniques such as HMBC, HSQC, COSY, NOESY, and HRESIMS. Electronic circular dichroism (ECD) calculations were used to estimate its absolute configuration. Subsequently, the newly identified compound was evaluated for its potential to attenuate palmitate-induced viability, demonstrating a significant increase in viability in MIN6 cells.

KEYWORDS

Litsea glutinosa
aporphine alkaloids
palmitate-induced viability

SUPPORTING INFORMATION

Supporting Information

Download File A9-427-RNP-2308-2875-SI.pdf (1.92 MB)