JOURNAL 2929


Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 1 January-February
PAGES
p.125 - 135
STATISTICS
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AUTHORS
  • Da-min Jung
  • Sangsoo Lee
  • Jin P. Kim
  • Kee K. Kim
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Despite the known physiological effects of Allium hookeri Thwaites (A. hookeri) on metabolism, the effects of ingestion of the extract on hematological parameters and exercise capacity are largely unknown. We aimed to investigate the hypothesis that water extracts of A. hookeri root (WEAH) would improve hematological parameters and promote exercise capacity. The intake of WEAH-containing feed significantly reduced the weight of white adipose tissue and the amount of total cholesterol in the blood, but it did not affect the body weight of mice. WEAH intake enhanced the muscular endurance of mice in treadmill endurance tests. The cross-sectional areas of muscle fibers in the gastrocnemius muscle of the WEAH-fed mice were larger than those in the control mice. WEAH promoted myoblast myogenesis by increasing the expression of the myogenic protein myosin heavy chain 3 and myotube formation. Taken together, our results suggest that A. hookeri may be valuable in the development of preventive and therapeutic medicines for sarcopenia as well as in providing basic knowledge of muscular functions.

KEYWORDS
  • Allium hookeri
  • muscular endurance
  • muscle cross-sectional area
  • myosin heavy chain 3
  • myoblast

SUPPORTING INFORMATION


Supporting Information https://www.youtube.com/watch?v=Q9T3K7-DRMA
Download File A6-433-RNP-2310-2929-SI.pdf (197.39 KB)