JOURNAL 2971


Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 1 January-February
PAGES
p.107 - 113
STATISTICS
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AUTHORS
  • Tran Thi Minh
  • Ho Khanh Toan
  • Duong Hoang Thuc
  • Tran Thi Minh Trang
  • Do Minh Hieu
  • Vu Dinh Hoang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Chemical investigation of the EtOAc extract from the aerial parts of Acrostichum aureum distributed along coastlines of Vietnam lead to the isolation of a new ecdysteroid, named pterosterone 20,22-acetonide (1), along with twelve known compounds (2-13). Their structures were elucidated by spectroscopic methods including 1D, 2D NMR and HR-ESI-MS analysis as well as comparison with the results of previous studies. Five ecdysteroids (1-5) were evaluated for their cytotoxic activity against the LU-1, MCF7 and HepG2 human cancer cell lines using the SRB assay. Ecdysteroids 1 and 2 having a 20,22-dimethyl acetal group showed cytotoxicity against all tested cell lines with IC50 values in the range 51.59 to 60.14 μM. The other compounds were considered as inactive in this test.

KEYWORDS
  • Acrostichum aureum
  • Pteridaceae
  • ecdysteroid
  • flavonoid
  • spectroscopic analyses
  • cytotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File A4-431-RNP-2311-2971-SI.pdf (4.47 MB)