JOURNAL 3038
Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 3 May-June
Year: 2024 Issue: 3 May-June
PAGES
p.363 - 368
p.363 - 368
STATISTICS
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Viewed 752 times.
AUTHORS
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Le Thi Tu Anh
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Hoang Thai Dang
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Nguyen Thi Thu Ha
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Nguyen Thanh Tra
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Nguyen Thi Thuy Linh
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Ba Thi Cham
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Bui Thi Thuy Luyen
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Hoang Huy Do
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Tiep Khac Nguyen
GRAPHICAL ABSTRACT
ABSTRACT
Nine known compounds were isolated from the P. serrata roots and showed promising inhibitory activity against α-glucosidase. The molecular docking study of them was exhibited the 4-hydroxyl group in the aromatic ring of benzoic acid derivatives improves the bioactivity. Network pharmacology was performed to investigate the molecular mechanisms of isolated compounds and suggested that the insulin resistance pathway would be a primary mechanism of action. This is the first time the α-glucosidase inhibitors of P. serrata roots were reported.
KEYWORDS- Polyscias serrata
- α-glucosidase inhibitor
- molecular docking
- network pharmacology
