JOURNAL 3202
Records of Natural Products
Year: 2024 Issue: 4 July-August
p.452 - 457
Viewed 621 times.
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Qingyu Zhong
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Xiaowei Meng
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Jiarong Li
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Qing Zhu
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Qiwan Zheng
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Ronghua Liu
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Lanying Chen
GRAPHICAL ABSTRACT
ABSTRACT
Abstract: A new benzofuran, named as (2S,3S)-5,6-dimethoxy-3-methyl-2-(3’-hydroxyphenyl)-2,3-dihydrobenzofuran (1), along with the six known isoflavonoids, 2'-hydroxy-4',7-dimethoxyisoflavone (2), 2′-methoxybiochanin A (3), tectorigenin (4), calycosin (5), 7-hydroxy-2',4',5'-trimethoxyisoflavone (6) , orobol (7) were isolated from the heartwood of Dalbergia odorifera T.Chen. The structure of compounds was characterised by NMR spectroscopic data and comparisons with relevant literature data. The absolute structural configuration of compound 1 was determined through X-ray single crystal diffraction. Moreover, compounds 1-7 have no significant cytotoxic effects on H9c2 cells (IC50 > 200 µM). Compound 1-7 exhibit a significant protective effect against H/R (hypoxia/reoxygenation) induced H9c2 cell damage at 10~40, 5~40, 5~40, 5~40, 5~40, 5~40 and 5~10 µM (P＜0.05).
KEYWORDS- Dalbergia odorifera T.Chen
- benzofuran
- H9c2
- hypoxia/reoxygenation
