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Isolation of New Secondary Metabolites from Kedrostis gijef and Evaluation of Their α-Glucosidase Inhibitory Activity

Original Article

JOURNAL 3236

Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 4 July-August
PAGES
p.393 - 404
DOI ADDRESS
http://doi.org/10.25135/rnp.468.2405.3236
STATISTICS
Viewed 507 times.
AUTHORS
  • Mahmoud Mubarek
  • Fahd M. Abdelkarem
  • Ahmed Othman
  • Masako Matsumoto
  • Fangjing Li
  • Kuniyoshi Shimizu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Four new polyoxygenated cucurbitane triterpene glycosides named kedrojiftene A-D (4-7), were isolated via different chromatographic techniques along with three phenolic compounds (1-3) from the crude extract of Kedrostis gijef. The isolated compounds were elucidated based on 1D, 2D-NMR spectroscopic analyses, HRESIMS and comparison with the related metabolites in literature. In bioassay, the α-glucosidase inhibitory assay for the isolated compounds was carried out and compounds (1-3) showed significant inhibitory activities.

 KEYWORDS
  • Kedrostis gijef
  • triterpene
  • cucurbitane
  • phenolic
  • α-glucosidase

SUPPORTING INFORMATION

identification cert

The plant identification cerificate issued by the Herbarium of the Desert Research Center

Download File plant Ident.pdf (396.2 KB)
Supporting Information
Download File A2-468-RNP-2405-3236-SI.pdf (7.6 MB)