Two New Compounds from Arctium lappa Roots

Original Article

JOURNAL 3187

Records of Natural Products

VOLUME & ISSUE

Year: 2024 Issue: 5 September-October

PAGES

p.490 - 498

DOI ADDRESS

http://doi.org/10.25135/rnp.474.2404.3187

STATISTICS

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AUTHORS

Qingyu Yang
Jun Chi
Weijin Zhang
Lingxia Zhang
Zhimin Wang
Liping Dai

GRAPHICAL ABSTRACT

ABSTRACT

A new caffeoylquinic acid, 1, 5-di-O-caffeoyl-3-O-(1-O-methoxy-2-O-caffeoyl-4-maloyl)-quinic acid (1), and a new 5-hydroxymethylfurfural dimer, 5-(((2-methoxymethyl) furan-5-methanol) methyl) furan-2-carbaldehyde (2), were discovered from Arctium lappa roots. A comprehensive HRMS, UV, IR, 1D and 2D NMR techniques were used for structural identification. These two compounds had Nitric Oxide (NO) inhibitory activity in lipopolysaccharide (LPS)-stimulated RAW 264.7 inflammatory cell in a dose-dependent manner.

KEYWORDS

Arctium lappa roots
caffeoylquinic acid
5-hydroxymethylfurfural derivative
anti-inflammatory activity

SUPPORTING INFORMATION

Supporting Information

Download File A2-474-RNP-2404-3187-SI.doc (81.37 MB)