2-Bisabolen-1,10,11,12-tetraol, A New Bisabolane Sesquiterpene from Marine Alga-Sourced Aspergillus taichungensis 299 and Its Antibacterial Activity against Common Pediatric Pathogens

Short Report

JOURNAL 3394

Records of Natural Products

VOLUME & ISSUE

Year: 2025 Issue: 1 January-February

PAGES

p.107 - 111

DOI ADDRESS

http://doi.org/10.25135/rnp.496.2501.3394

STATISTICS

Viewed 94 times.

AUTHORS

Lianlian Ji
Xiu Weng
Zhishu Li
Guan-yi Cao
Minli Pan

GRAPHICAL ABSTRACT

ABSTRACT

One new bisabolane sesquiterpene, 2-bisabolen-1,10,11,12-tetraol (1), and three known ones, (3R, 6R, 7S, 10S)-1-bisabolen-3,10,11-triol (2), (3R, 6S, 7R)-1,10-bisaboladien-3-ol (3), and nor-bisabolan-1,11-diol (4), were acquired from the extract of Aspergillus taichungensis 299 isolated from the inner tissue of marine red alga Gelidium amansii. Their structures were determined by comprehensive analysis of 1D/2D NMR and HRESIMS data. The antibacterial assay showed that 1 displayed inhibitory activities against the growth of three common pediatric pathogens, Haemophilus influenzae, Streptococcus agalactiae, and Streptococcus pneumoniae, with the MIC values of 16, 8, and 32 μg/mL, respectively.

KEYWORDS

Bisabolane sesquiterpene
Aspergillus taichungensis
structure elucidation
antibacterial activity

SUPPORTING INFORMATION

2-Bisabolen-1,10,11,12-tetraol, A New Bisabolane Sesquiterpene from Marine Alga-Sourced Aspergillus taichungensis 299 and Its Antibacterial Activity against Common Pediatric Pathogens

Download File R-supporting information.doc (1.32 MB)