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An Undescribed Ingenane Glucoside Isolated from the Roots of Euphorbia fischeriana Steud and Its Anti-inflammatory Activity

Original Article

JOURNAL 3589

Records of Natural Products
VOLUME & ISSUE
Year: 2025 Issue: 6 November-December
PAGES
p.734 - 738
DOI ADDRESS
https://doi.org/10.25135/rnp.548.2507.3589
STATISTICS
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AUTHORS
  • Ling-Ling Cai
  • En-Zhi Liu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Abstract: A new compound, ingenol 3-O-β-D-glucopyranoside (1) was isolated from the roots of Euphorbia fischeriana Steud. (Euphorbiaceae), together with four known compounds (2−5). The structure of compound 1 was characterized by a combination of spectroscopic techniques and X-ray crystallography. Moreover, biological evaluation revealed that compound 1 exhibited potent inhibitory effect on NO production in lipopolysaccharide-stimulated RAW 264.7 macrophages, with IC50 value of 25.24 ±3.48 μM.

 KEYWORDS
  • Euphorbia fischeriana Steud.
  • Ingenol 3-O-β-D-glucopyranoside
  • Anti-inflammatory activity

SUPPORTING INFORMATION

Supporting Information
Download File A8-548-RNP-2507-3589-SI.pdf (1003.61 KB)