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Cyclocarioside Z15, a new 3,4-seco dammarane triterpenoid glycoside fromthe leaves of Cyclocarya paliurus with α-glucosidase inhibitory activity

Short Report

JOURNAL 3800

Records of Natural Products
VOLUME & ISSUE
Year: 2026 Issue: 4
PAGES
p.3 - 2
DOI ADDRESS
http://doi.org/10.25135/rnp.2602.3800
STATISTICS
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AUTHORS
  • Qian Yao
  • Xifan Wei
  • Lu Wang
  • Rui Gui
  • Yi-Heng Liu
  • Dan-Dan Li
  • Xiao-Ai He
  • Xia Yu
  • Gui-Ming Deng
  • Kang-Ping Xu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new 3,4-seco dammarane triterpenoid glycoside, cyclocarioside Z15 (1), along with three known compounds cypaliuruside B (2), 2α,3α,23-trihydroxyurs-12,20(30)-dien-28-oic acid (3) and asiatic acid (4) were isolated from the leaves of Cyclocarya paliurus. The chemical structures were elucidated by 1D and 2D NMR, HR-ESI-MS, and acid hydrolysis. All compounds were measured for their α-glucosidase inhibitory activity, and only compound 1 exhibited weak activity with an IC50 value of 77.98 μM.

 KEYWORDS
  • Cyclocarya paliurus
  • 3,4-seco dammarane triterpenoid glycoside
  • α-glucosidase inhibitory activity

SUPPORTING INFORMATION

Supporting Information
Download File RNP-2602-3800-SI.pdf (2.22 MB)