JOURNAL 3202


Records of Natural Products
VOLUME & ISSUE
Available Online: July 05,2024
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.464.2404.3202
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 195 times.
AUTHORS
  • Qingyu Zhong
  • Xiaowei Meng
  • Jiarong Li
  • Qing Zhu
  • Qiwan Zheng
  • Ronghua Liu
  • Lanying Chen
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Abstract: A new benzofuran, named as (2S,3S)-5,6-dimethoxy-3-methyl-2-(3’-hydroxyphenyl)-2,3-dihydrobenzofuran (1), along with the six known isoflavonoids, 2'-hydroxy-4',7-dimethoxyisoflavone (2), 2′-methoxybiochanin A (3), tectorigenin (4), calycosin (5), 7-hydroxy-2',4',5'-trimethoxyisoflavone (6) , orobol (7) were isolated from the heartwood of Dalbergia odorifera T.Chen. The structure of compounds was characterised by NMR spectroscopic data and comparisons with relevant literature data. The absolute structural configuration of compound 1 was determined through X-ray single crystal diffraction. Moreover, compounds 1-7 have no significant cytotoxic effects on H9c2 cells (IC50 > 200 µM). Compound 1-7 exhibit a significant protective effect against H/R (hypoxia/reoxygenation) induced H9c2 cell damage at 10~40, 5~40, 5~40, 5~40, 5~40, 5~40 and 5~10 µM (P<0.05).

KEYWORDS
  • Dalbergia odorifera T.Chen
  • benzofuran
  • H9c2
  • hypoxia/reoxygenation

SUPPORTING INFORMATION


Supporting Information
Download File 464-RNP-2404-3202-SI.pdf (2.29 MB)