JOURNAL 2145


Records of Natural Products
VOLUME & ISSUE
Available Online: October 25,2021
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.283.2107-2145
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Guoqing Wu
  • Zilong Zhang
  • Hao Fan
  • Dongdong Zhang
  • Wenli Huang
  • Huawei Zhang
  • Yuze Li
  • Xiaomei Song
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new iridoid glycoside, (5S,7S,8S,9R)-7- hydroxy-∆4,11-dihyronepeta-1,3-diol-8-O-β-D-glucopyranosyl (1), along with 5 known compounds, dioscoridin A (2), jatamanin J (3), longiflorone (4), apigenin-8-O-β-D-glucopyranoside (5), isosakuranetin-5-O-rutinoside (6), were isolated from the Valeriana officinalis L. Their structures were determined by extensive analysis using various spectroscopic techniques. Moreover, the cytotoxic activity assay toward three human tumor cell (A549, HCT116 and SW620) lines were evaluated by the MTT method in vitro for compounds 1-2, using cisplatin as positive control. Experimental results showed that these compounds displayed weak cytotoxicity in the human cancer cell lines. Notably, compounds 2, 3 and 6 were firstly isolated from this plant, compound 4 was isolated from the genus Valeriana for the first time, compound 5 was isolated for the first time from Valerianaceae family.

KEYWORDS
  • Iridoids
  • Valeriana officinalis L.
  • Valerianaceae
  • cytotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File 283-RNP-2107-2145-SI.pdf (3.06 MB)