JOURNAL 3427
Records of Natural Products
VOLUME & ISSUE
Available Online: April 07,2025
Available Online: April 07,2025
PAGES
p.1 - 5
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.503.2502.3427 (DOI number will be activated after the manuscript has been available in an issue.)
http://doi.org/10.25135/rnp.503.2502.3427 (DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 113 times.
Viewed 113 times.
GRAPHICAL ABSTRACT
ABSTRACT
Lignans, such as podophyllotoxin, schisandrin, and silymarin, are known for their notable biological activities. In our study, a new lignan, named melaleucin D (1), was isolated from the leaves and stems of the plant Melaleuca bracteata F. Muell. The planar structure was determined by combining 1H NMR/13C NMR/ COSY/HSQC/HMBC spectra and HRESIMS data. The absolute configuration was established by comparing the experimental circular dichroism (CD) data with the calculated theoretical ECD data. Compound 1 contained an unusual dioxane moiety. The antibacterial assay revealed that compound 1 did not exhibit a zone of inhibition against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 25922 at a concentration of 256 mg/mL.
KEYWORDS- Melaleuca bracteata F. Muell.
- lignan
- separation
- structure elucidation
