JOURNAL 2001


Records of Natural Products
VOLUME & ISSUE
Available Online: August 18,2021
PAGES
p.1 - 13
DOI ADDRESS
http://doi.org/10.25135/rnp.275.2103.2001
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 84 times.
AUTHORS
  • Mohammed S. Abdel-raziq
  • Fatma M. Abdel Bar
  • Sylvia A. Ashamallah
  • Nashwa Barakat
  • Ahmed Gohar
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Obesity is a major risk factor in many health problems. This study explored the anti-obesity and antihyperlipidemic effects of Musa cavendishii Lamb. leaves. Doses of 1200 mg/kg of M. cavendishii methanol extract, or 300 mg/kg of fractions, were given to C57BL/6J mice fed with a high-fat diet (HFD) for 7 weeks. The reduction in fat volume was determined using CT scan and histopathological examination of mice livers. The results showed that the n-hexane and the EtOAc fractions reduced the body fat volume to 2.0% and 2.2% respectively, compared to 20.1% in the HFD group. Also, treated groups showed almost normal liver architecture with no fat vacuoles compared to the HFD group. Moreover, the treated groups showed a reduction in the levels of some obesity-related biochemical parameters, including plasma glucose, cholesterol, and triglycerides levels. Chromatographic fractionation of the bioactive n-hexane extract afforded four known compounds viz., palmitic acid (1), 5-methyl-5-(4,8,12-trimethyl-tridecyl)-dihydro-furan-2-one (2), cycloeucalenol (3), and stigmasterol (4). These compounds were in vitro and in silico studied for their pancreatic lipase (PL) inhibition. Compound 2 showed remarkable PL inhibition (89.8%) compared to orlistat (85.0%) at 200 µM, which was in full agreement with the docking scores (-7.19 and -4.05, respectively).

KEYWORDS
  • musa cavendishii
  • anti-obesity
  • antihyperlipidemic
  • banana leaf
  • anti-adipogenesis
  • pancreatic lipase